Funding Awarded for Developing Strong Biomimetic Adhesive

September 24, 2013

Our lab has received a three-year research grant entitled “Biomimetic Tissue Adhesive with Mechanically Tough Hydrogel Support” from the National Institutes of Health. The objectives of this project are 1) to functionalize mechanical tough hydrogel with marine adhesive moiety to develop novel bioadhesive with elevated adhesive strength and tunable degradation rate and 2) to evaluate its biocompatibility in culture and subcutaneous implantation experiments. The central hypothesis is that an optimal combination of elevated bulk material toughness with strong water-resistant interfacial binding strength will yield a tissue adhesive with superior adhesive properties (i.e., work of adhesion). The long term goal of this project is to develop tissue adhesives with strong adhesive strength and biomechanical properties matching those of native tissue to repair tissues that routinely experience large, repeated loads (e.g., tendon). Dr. Ray Vanderby of University of Wisconsin-Madison will serve as a consultant for this project.

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