Mussel-Inspired Polydopamine-coated Silk Fibroin as a Promising Biomaterial

S Kianersi, AAA Varjani, A Solouk, J Ai, BP Lee
April 2, 2020
Bioinspired, Biomimetic and Nanobiomaterials, 2020, Accepted

Silk fibroin (SF) is one of the natural biomaterials with promising and growing potential in different clinical applications such as corneal transplantation, donor site skin substitute and tympanic membrane. Some of the SFs which are extracted from mulberry silkworm do not have the Arginyl-glycyl-aspartic acid (RGD) sequence to properly support cell adhesion and proliferation. Therefore, in the current study, polydopamine (PDA) coated SF are prepared to provide RGD sequence and the effect of PDA coating on different properties of SF is investigated. The results are also compared with amniotic membrane (AM) that is a commercially available natural biomaterial for mentioned applications. Raman spectra depicted characteristic peaks at 1581 and 1370 cm−1 that demonstrated the formation of the coating layer on the surface of the films. The results showed that coating led to a little decrease in membrane transparency but still transparent enough to provide vivid vision through membrane, no significant difference in surface hydrophilicity, smoother surface and improved cell attachment and distribution.

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