Injectable dopamine-modified poly(ethylene glycol) nanocomposite hydrogel with enhanced adhesive property and bioactivity

Y Liu,‡ H Meng,‡ S Konst, R Sarmiento, R Rajachar, and BP Lee* ‡ Contributed equally
September 15, 2014
ACS Applied Materials & Interfaces, 6 (19), 16982–16992, 2014.

A synthetic mimic of mussel adhesive protein, dopamine-modified 4-armed poly(ethylene glycol) (PEGD4), was combined with a synthetic nano-silicate, Laponite (Na0.7+(Mg5.5Li0.3Si8)O20(OH)4)0.7-) to form an injectable naoncomposite tissue adhesive hydrogel. Incorporation of up to 2 wt% Laponite significantly reduced the cure time while enhancing the bulk mechanical and adhesive properties of the adhesive due to strong interfacial binding between dopamine and Laponite. The addition of Laponite did not alter the degradation rate and cytocompatibility of PEG-D4 adhesive. Based on subcutaneous implantation in rat, PEG-D4 nanocomposite hydrogels elicited minimal inflammatory response and exhibited an enhanced level of cellular infiltration as compared to Laponite-free samples. The addition of Laponite is potentially a simple and effective method to promote bioactivity in a bio-inert, synthetic PEG-based adhesive while simultaneously enhance its mechanical and adhesive properties.

Laponite PEG toc small

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