A moldable nanocomposite hydrogel composed of a mussel-inspired polymer and a nanosilicate as a fit-to-shape tissue sealant

Y Liu, H Meng, Z Qian, N Fan, W Choi, F Zhao, and BP Lee*
March 15, 2017
Angewandte Chemie International Edition, 56, 4224-4228, 2017.
Abstract:

The engineering of bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We have developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and the nanosilicate Laponite, without the use of cytotoxic oxidants. The hydrogel transitioned from a reversibly cross-linked network formed by dopamine–Laponite interfacial interactions to a covalently cross-linked network through the slow autoxidation and cross-linking of catechol moieties. Initially, the hydrogel could be remolded to different shapes, could recover from large strain deformation, and could be injected through a syringe to adhere to the convex contour of a tissue surface. With time, the hydrogel solidified to adopt the new shape and sealed defects on the tissue. This fit-to-shape sealant has potential in sealing tissues with non-flat geometries, such as a sutured anastomosis.

Figure-Sealant

The video below shows the application of the adhesive on to a non-flat tissue surface (i.e., sutured anastomosis) without dripping.

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