Adhesion Mechanism and Biocompatibility of Biomimetic Adhesive Moiety

March 5, 2015

The catechol adhesive found in mussel adhesive proteins is capable of binding to both organic and inorganic surfaces through either irreversible covalent or strong reversible bonds. Incorporation of various catechol derivatives into synthetic polymers has imparted these materials with strong adhesive properties. We seek to design polymer model systems to separately elucidate the crosslinking and interfacial binding chemistries and biocompatibility of the biomimetic adhesive moiety. Specifically, the effect of environmental factors (i.e., pH) and chemical modification of the catechol side chain on the crosslinking chemistries and reactive oxygen species (ROS) generation are of great interest. ROS, such as hydrogen peroxide, has numerous biological effects and its production needs to be tightly controlled to optimize the performance of mussel-mimetic biomaterials depending on the intended application.

 

Related Publications:

H Meng, Y Liu, BP Lee.* “Model polymer system for investigating the generation of hydrogen peroxide and its biological responses during the crosslinking of mussel adhesive moiety” Acta Biomaterialia, 2016, Accepted. [Link]

 

H Meng, Y Li, M Faust, S Konst, BP Lee.* “Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety” Acta Biomaterialia, 17, 160-169, 2015. [Link]

 

X Ding, GK Vegesna, A Winter, H Meng, BP Lee.* “Nitro-group functionalization of dopamine and its contribution to the viscoelastic properties of catechol-containing nanocomposite hydrogel” Macromolecular Chemistry and Physics, 216, 1109-1119, 2015. [Link]

 

M Cencer, M Murley, Y Liu and BP Lee.* “Effect of nitro-functionalization on the cross-linking and bioadhesion of biomimetic adhesive moiety” Biomacromolecules, 16, 404-410, 2015. [Link]

 

M Cencer, Y Liu, A Winter, M Murley, H Meng, and BP Lee.* “Effect of pH on the rate of curing and bioadhesive properties of dopamine functionalized poly(ethylene glycol) hydrogels” Biomacromolecules, 15, 2861–2869, 2014. [Link]

 

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